4E6Q

JAK2 kinase (JH1 domain) triple mutant in complex with compound 12

Summary for 4E6Q

Entry DOI	10.2210/pdb4e6q/pdb
Related	4E4L 4E4M 4E4N 4E5W 4E6D
Descriptor	Tyrosine-protein kinase JAK2, 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine (3 entities in total)
Functional Keywords	jak2, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein (By similarity): O60674
Total number of polymer chains	2
Total formula weight	71113.00
Authors	Murray, J.M. (deposition date: 2012-03-15, release date: 2012-05-30, Last modification date: 2012-07-11)
Primary citation	Kulagowski, J.J.,Blair, W.,Bull, R.J.,Chang, C.,Deshmukh, G.,Dyke, H.J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Harrison, T.K.,Hewitt, P.R.,Liimatta, M.,Hurley, C.A.,Johnson, A.,Johnson, T.,Kenny, J.R.,Bir Kohli, P.,Maxey, R.J.,Mendonca, R.,Mortara, K.,Murray, J.,Narukulla, R.,Shia, S.,Steffek, M.,Ubhayakar, S.,Ultsch, M.,van Abbema, A.,Ward, S.I.,Waszkowycz, B.,Zak, M. Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors. J.Med.Chem., 55:5901-5921, 2012 Cited by PubMed: 22591402 DOI: 10.1021/jm300438j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.948 Å)

Structure validation