4E6Q
JAK2 kinase (JH1 domain) triple mutant in complex with compound 12
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 298 | 35225.1 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2, JAK-2 |
2 | A, B | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | non-polymer | 331.4 | 2 | Chemie (0NV) | |||
3 | water | water | 18.0 | 183 | Chemie (HOH) |
Sequence modifications
A, B: 835 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Arg 853 | Gln 853 | ENGINEERED MUTATION |
Phe 931 | Tyr 931 | ENGINEERED MUTATION |
Glu 939 | Asp 939 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70450.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 662.8 | |
All* | Total formula weight | 71113.0 |