4E6A
p38a-PIA23 complex
Summary for 4E6A
Entry DOI | 10.2210/pdb4e6a/pdb |
Related | 1P38 2NPQ 4E5A 4E5B 4E6C 4E8A |
Descriptor | Mitogen-activated protein kinase 14, (2S)-2-methoxy-3-(octadecyloxy)propyl (1R,2R,3R,4S,6S)-2,3,4-trihydroxy-6-(2-methylpropoxy)cyclohexyl hydrogen (S)-phosphate (3 entities in total) |
Functional Keywords | map kinase, p38, signal transduction, alternative activation modes, lipid binding site, pia, perifosine, kinase fold, kinase, substrates, phosphorylation, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41984.02 |
Authors | Livnah, O.,Tzarum, N.,Eisenberg-Domovich, Y. (deposition date: 2012-03-15, release date: 2012-10-31, Last modification date: 2024-02-28) |
Primary citation | Tzarum, N.,Eisenberg-Domovich, Y.,Gills, J.J.,Dennis, P.A.,Livnah, O. Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424:339-353, 2012 Cited by PubMed: 23079240DOI: 10.1016/j.jmb.2012.10.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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