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4E4Q

Crystal structure of PPARgamma with the ligand FS214

Summary for 4E4Q
Entry DOI10.2210/pdb4e4q/pdb
Related3B3K 3K8S 4E4K
DescriptorPeroxisome proliferator-activated receptor gamma, (2R)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid (3 entities in total)
Functional Keywordsbundle of alpha-helices and a small four-stranded beta-sheet, transcription factor, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight65748.09
Authors
Pochetti, G.,Montanari, R.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Carbonara, G.,Piemontese, L.,Lavecchia, A.,Novellino, E. (deposition date: 2012-03-13, release date: 2013-01-23, Last modification date: 2024-02-28)
Primary citationLaghezza, A.,Pochetti, G.,Lavecchia, A.,Fracchiolla, G.,Faliti, S.,Piemontese, L.,Di Giovanni, C.,Iacobazzi, V.,Infantino, V.,Montanari, R.,Capelli, D.,Tortorella, P.,Loiodice, F.
New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression.
J.Med.Chem., 56:60-72, 2013
Cited by
PubMed: 23171045
DOI: 10.1021/jm301018z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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