4E06
Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
Summary for 4E06
Entry DOI | 10.2210/pdb4e06/pdb |
Related | 4E05 |
Descriptor | Thrombin, Salivary anti-thrombin peptide anophelin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Anopheles albimanus (New world malaria mosquito) More |
Total number of polymer chains | 3 |
Total formula weight | 40663.65 |
Authors | Figueiredo, A.C.,de Sanctis, D.,Gutierrez-Gallego, R.,Cereija, T.B.,Macedo-Ribeiro, S.,Fuentes-Prior, P.,Pereira, P.J.B. (deposition date: 2012-03-02, release date: 2012-12-05, Last modification date: 2023-09-13) |
Primary citation | Figueiredo, A.C.,de Sanctis, D.,Gutierrez-Gallego, R.,Cereija, T.B.,Macedo-Ribeiro, S.,Fuentes-Prior, P.,Pereira, P.J. Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proc.Natl.Acad.Sci.USA, 109:E3649-E3658, 2012 Cited by PubMed: 23223529DOI: 10.1073/pnas.1211614109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.196 Å) |
Structure validation
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