4DZ8

human IgG1 Fc fragment Heterodimer

Summary for 4DZ8

• Entry DOI: 10.2210/pdb4dz8/pdb
• Descriptor: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: fc fragment, antibody, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01857 P01857
• Total number of polymer chains: 2
• Total formula weight: 53257.61

Authors

Strop, P. (deposition date: 2012-02-29, release date: 2012-08-01, Last modification date: 2020-07-29)

• Primary citation: Strop, P.,Ho, W.H.,Boustany, L.M.,Abdiche, Y.N.,Lindquist, K.C.,Farias, S.E.,Rickert, M.,Appah, C.T.,Pascua, E.,Radcliffe, T.,Sutton, J.,Chaparro-Riggers, J.,Chen, W.,Casas, M.G.,Chin, S.M.,Wong, O.K.,Liu, S.H.,Vergara, G.,Shelton, D.,Rajpal, A.,Pons, J.; Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair.; J.Mol.Biol., 420:204-219, 2012; PubMed: 22543237; DOI: 10.1016/j.jmb.2012.04.020

Experimental method

X-RAY DIFFRACTION (1.91 Å)