4DZ8

human IgG1 Fc fragment Heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ig gamma-1 chain C region	polymer	223	25157.5	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (human)
2	B (B)	Ig gamma-1 chain C region	polymer	223	25173.4	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (human)
3	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	2	In PDB GlyTouCan (G80858MF)
4	E, F (A, B)	water	water		18.0	436	Chemie (HOH)

Sequence modifications

A: 225 - 447 (UniProt: P01857)

PDB	External Database	Details
Arg 228	Pro 111	engineered mutation
Glu 368	Leu 251	microheterogeneity
Arg 409	Lys 292	microheterogeneity

B: 225 - 447 (UniProt: P01857)

PDB	External Database	Details
Glu 228	Pro 111	engineered mutation
Glu 368	Leu 251	microheterogeneity
Arg 409	Lys 292	microheterogeneity

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50330.9
Branched	Number of molecules	2
	Total formula weight	2926.7
All*	Total formula weight	53257.6

*Water molecules are not included.