4DX7
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
Summary for 4DX7
Entry DOI | 10.2210/pdb4dx7/pdb |
Related | 4DX5 4DX6 |
Descriptor | Acriflavine resistance protein B, DARPIN, DODECYL-BETA-D-MALTOSIDE, ... (10 entities in total) |
Functional Keywords | darpin, multidrug efflux protein, membrane protein, transport protein |
Biological source | Escherichia coli More |
Cellular location | Cell inner membrane; Multi-pass membrane protein: P31224 |
Total number of polymer chains | 5 |
Total formula weight | 388258.58 |
Authors | Eicher, T.,Cha, H.,Seeger, M.A.,Brandstaetter, L.,El-Delik, J.,Bohnert, J.A.,Kern, W.V.,Verrey, F.,Gruetter, M.G.,Diederichs, K.,Pos, K.M. (deposition date: 2012-02-27, release date: 2012-05-02, Last modification date: 2024-02-28) |
Primary citation | Eicher, T.,Cha, H.J.,Seeger, M.A.,Brandstatter, L.,El-Delik, J.,Bohnert, J.A.,Kern, W.V.,Verrey, F.,Grutter, M.G.,Diederichs, K.,Pos, K.M. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc.Natl.Acad.Sci.USA, 109:5687-5692, 2012 Cited by PubMed: 22451937DOI: 10.1073/pnas.1114944109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.253 Å) |
Structure validation
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