4DX7
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Acriflavine resistance protein B | polymer | 1057 | 114736.3 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli | |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | SYNTHETIC CONSTRUCT (ARTIFICIAL GENE) | ||
| 3 | F, G, H, I, O... (A, B, C) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 7 | Chemie (LMT) | |||
| 4 | J, K, R (A, B) | DOXORUBICIN | non-polymer | 543.5 | 3 | Chemie (DM2) | |||
| 5 | CA, L, W, Y (C, A, B) | DODECANE | non-polymer | 170.3 | 4 | Chemie (D12) | |||
| 6 | AA, M, N, S (C, A, B) | DECANE | non-polymer | 142.3 | 4 | Chemie (D10) | |||
| 7 | Q (B) | DODECYL-ALPHA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMU) | |||
| 8 | T, U, Z (B, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 9 | BA, V (C, B) | HEXANE | non-polymer | 86.2 | 2 | Chemie (HEX) | |||
| 10 | DA, EA, FA, GA, HA (A, B, C, D, E) | water | water | 18.0 | 1700 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 380844.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 7414.6 | |
| All* | Total formula weight | 388258.6 |
