4DO3

Structure of FAAH with a non-steroidal anti-inflammatory drug

Summary for 4DO3

Entry DOI	10.2210/pdb4do3/pdb
Related	1M5T 2VYA 3LJ7
Descriptor	Fatty-acid amide hydrolase 1, CHLORIDE ION, CYCLOHEXANE AMINOCARBOXYLIC ACID, ... (5 entities in total)
Functional Keywords	amidase, hydrolase, anandamide, nsaid, drug, cox, inhibitor, inflammation, pain, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rattus norvegicus (rat)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	126614.04
Authors	Garau, G. (deposition date: 2012-02-09, release date: 2013-01-23, Last modification date: 2023-09-13)
Primary citation	Bertolacci, L.,Romeo, E.,Veronesi, M.,Magotti, P.,Albani, C.,Dionisi, M.,Lambruschini, C.,Scarpelli, R.,Cavalli, A.,De Vivo, M.,Piomelli, D.,Garau, G. A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase. J.Am.Chem.Soc., 135:22-25, 2013 Cited by PubMed: 23240907 DOI: 10.1021/ja308733u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation