4DO3

Structure of FAAH with a non-steroidal anti-inflammatory drug

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fatty-acid amide hydrolase 1	polymer	571	62872.4	2	UniProt (P97612) Pfam (PF01425) In PDB	Rattus norvegicus (rat)	Anandamide amidohydrolase 1, Oleamide hydrolase 1
2	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
3	A, B	CYCLOHEXANE AMINOCARBOXYLIC ACID	non-polymer		143.2	2	Chemie (OHO)
4	A, B	(2S)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid	non-polymer		273.7	2	Chemie (0LA)
5		water	water		18.0	533	Chemie (HOH)

Sequence modifications

A, B: 32 - 575 (UniProt: P97612)

PDB	External Database	Details
Met 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag
His 576	-	expression tag
His 577	-	expression tag
His 578	-	expression tag
His 579	-	expression tag
His 580	-	expression tag
His 581	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	125744.8
Non-Polymers*	Number of molecules	5
	Total formula weight	869.2
All*	Total formula weight	126614.0

*Water molecules are not included.