4DKT
Crystal structure of human peptidylarginine deiminase 4 in complex with N-acetyl-L-threonyl-L-alpha-aspartyl-N5-[(1E)-2-fluoroethanimidoyl]-L-ornithinamide
Summary for 4DKT
Entry DOI | 10.2210/pdb4dkt/pdb |
Related PRD ID | PRD_000781 |
Descriptor | Protein-arginine deiminase type-4, Thr-Asp-F-amidine, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | alpha/beta-propeller, immunoglobulin-like, arginine citrullination, post-translational, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9UM07 |
Total number of polymer chains | 2 |
Total formula weight | 75540.59 |
Authors | Jones, J.E.,Slack, J.L.,Fang, P.,Zhang, X.,Subramanian, V.,Causey, C.P.,Coonrod, S.A.,Guo, M.,Thompson, P.R. (deposition date: 2012-02-04, release date: 2012-02-29, Last modification date: 2023-11-15) |
Primary citation | Jones, J.E.,Slack, J.L.,Fang, P.,Zhang, X.,Subramanian, V.,Causey, C.P.,Coonrod, S.A.,Guo, M.,Thompson, P.R. Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors. Acs Chem.Biol., 7:160-165, 2012 Cited by PubMed: 22004374DOI: 10.1021/cb200258q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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