4DHL
Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123
Summary for 4DHL
Entry DOI | 10.2210/pdb4dhl/pdb |
Descriptor | Purple acid phosphatase, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | catalytic c domain, n terminal domain, phosphatase, acid phosphatase, phosphoric monoester hydrolases, hydrolase, mo07123, maybridge, fragment, lysosome |
Biological source | Phaseolus vulgaris (French bean,kidney bean,string bean) |
Total number of polymer chains | 4 |
Total formula weight | 206786.41 |
Authors | Feder, D.,Clayton, D.J.,Hussein, W.M.,Schenk, G.,McGeary, R.,Guddat, L.W. (deposition date: 2012-01-29, release date: 2012-12-12, Last modification date: 2020-07-29) |
Primary citation | Feder, D.,Hussein, W.M.,Clayton, D.J.,Kan, M.W.,Schenk, G.,McGeary, R.P.,Guddat, L.W. Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80:665-674, 2012 Cited by PubMed: 22943065DOI: 10.1111/cbdd.12001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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