4DG9
Structure of holo-PA1221, an NRPS protein containing adenylation and PCP domains bound to vinylsulfonamide inhibitor
Summary for 4DG9
Entry DOI | 10.2210/pdb4dg9/pdb |
Related | 4DG8 |
Descriptor | PA1221, 5'-({[(2R,3R)-3-amino-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-{[oxido(oxo)phosphonio]oxy}butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-4-methylpentyl]sulfonyl}amino)-5'-deoxyadenosine (3 entities in total) |
Functional Keywords | anl superfamily, adenylation domain, peptidyl carrier protein, non-ribosomal peptide synthetase, nrps, pantetheine, vinylsulfonamide, valine adenylation, ligase-inhibitor complex, ligase/inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 68643.30 |
Authors | Mitchell, C.A.,Shi, C.,Aldrich, C.C.,Gulick, A.M. (deposition date: 2012-01-25, release date: 2012-05-02, Last modification date: 2023-09-13) |
Primary citation | Mitchell, C.A.,Shi, C.,Aldrich, C.C.,Gulick, A.M. Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains. Biochemistry, 51:3252-3263, 2012 Cited by PubMed: 22452656DOI: 10.1021/bi300112e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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