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4DG9

Structure of holo-PA1221, an NRPS protein containing adenylation and PCP domains bound to vinylsulfonamide inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005737cellular_componentcytoplasm
A0031177molecular_functionphosphopantetheine binding
A0043041biological_processamino acid activation for nonribosomal peptide biosynthetic process
A0044550biological_processsecondary metabolite biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE DG9 A 701
ChainResidue
APRO210
AGLY308
APRO309
ATHR310
ATHR314
AASP400
ALYS421
AASN423
AGLY424
ATYR425
AARG426
AASP214
ASER553
AHOH844
AHOH865
AHOH869
AHOH870
AHOH887
AHOH889
AHOH894
AGLY282
AGLY283
AASP284
AILE285
AASN305
AGLY306
ATYR307

Functional Information from PROSITE/UniProt
site_idPS00455
Number of Residues12
DetailsAMP_BINDING Putative AMP-binding domain signature. INFSSGTTGrPK
ChainResidueDetails
AILE167-LYS178

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PDB entries from 2024-07-24

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