4DCK
Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM
Summary for 4DCK
Entry DOI | 10.2210/pdb4dck/pdb |
Descriptor | Sodium channel protein type 5 subunit alpha, Calmodulin, Fibroblast growth factor 13, ... (5 entities in total) |
Functional Keywords | iq-motif, ef-hand, voltage-gated sodium channel regulation, nav1.5 ctd binds to fgf13 and cam. cam binds to ca2+., transport protein-transport protein regulator-signaling protein complex, transport protein-signaling protein complex, transport protein/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Multi-pass membrane protein: Q14524 Cytoplasm, cytoskeleton, spindle: P62158 |
Total number of polymer chains | 3 |
Total formula weight | 57904.94 |
Authors | Chung, B.C.,Wang, C.,Yan, H.,Pitt, G.S.,Lee, S.Y. (deposition date: 2012-01-17, release date: 2012-06-27, Last modification date: 2024-02-28) |
Primary citation | Wang, C.,Chung, B.C.,Yan, H.,Lee, S.Y.,Pitt, G.S. Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin. Structure, 20:1167-1176, 2012 Cited by PubMed: 22705208DOI: 10.1016/j.str.2012.05.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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