4DCK

Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sodium channel protein type 5 subunit alpha	polymer	168	19369.9	1	UniProt (Q14524) In PDB	Homo sapiens (human)	HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5
2	B	Calmodulin	polymer	149	16852.5	1	UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) In PDB	Homo sapiens (human)	CaM
3	C	Fibroblast growth factor 13	polymer	192	21609.6	1	UniProt (Q92913) Pfam (PF00167) In PDB	Homo sapiens (human)	FGF-13, Fibroblast growth factor homologous factor 2, FHF-2
4	B	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5		water	water		18.0	202	Chemie (HOH)

Sequence modifications

C: 10 - 192 (UniProt: Q92913)

PDB	External Database	Details
Met 1	-	expression tag
Ala 2	-	expression tag
Leu 3	-	expression tag
Leu 4	-	expression tag
Arg 5	-	expression tag
Lys 6	-	expression tag
Ser 7	-	expression tag
Tyr 8	-	expression tag
Ser 9	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	57832.0
Non-Polymers*	Number of molecules	3
	Total formula weight	72.9
All*	Total formula weight	57904.9

*Water molecules are not included.