4DCK
Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 5 subunit alpha | polymer | 168 | 19369.9 | 1 | UniProt (Q14524) | Homo sapiens (human) | HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5 |
| 2 | B (B) | Calmodulin | polymer | 149 | 16852.5 | 1 | UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) | Homo sapiens (human) | CaM |
| 3 | C (C) | Fibroblast growth factor 13 | polymer | 192 | 21609.6 | 1 | UniProt (Q92913) Pfam (PF00167) | Homo sapiens (human) | FGF-13, Fibroblast growth factor homologous factor 2, FHF-2 |
| 4 | D, E, F (B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | G, H, I (A, B, C) | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
C: 10 - 192 (UniProt: Q92913)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Arg 5 | - | expression tag |
| Lys 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Tyr 8 | - | expression tag |
| Ser 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57832.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 72.9 | |
| All* | Total formula weight | 57904.9 |
