4DCD

1.6A resolution structure of PolioVirus 3C Protease Containing a covalently bound dipeptidyl inhibitor

Summary for 4DCD

Entry DOI	10.2210/pdb4dcd/pdb
Related	3UR6 3UR9 4F49
Descriptor	Genome polyprotein, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (5 entities in total)
Functional Keywords	protease, poliovirus, antiviral inhibitors, dipeptidyl inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human poliovirus 1
Total number of polymer chains	1
Total formula weight	21439.32
Authors	Lovell, S.,Battaile, K.P.,Kim, Y.,Tiew, K.-C.,Mandadapu, S.R.,Alliston, K.R.,Groutas, W.C.,Chang, K.O. (deposition date: 2012-01-17, release date: 2012-09-05, Last modification date: 2023-09-13)
Primary citation	Kim, Y.,Lovell, S.,Tiew, K.C.,Mandadapu, S.R.,Alliston, K.R.,Battaile, K.P.,Groutas, W.C.,Chang, K.O. Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses. J.Virol., 86:11754-11762, 2012 Cited by PubMed: 22915796 DOI: 10.1128/JVI.01348-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation