4CPE
Wild-type streptavidin in complex with love-hate ligand 1 (LH1)
Summary for 4CPE
Entry DOI | 10.2210/pdb4cpe/pdb |
Related | 4CPF 4CPH 4CPI |
Descriptor | STREPTAVIDIN, (3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N-{2-[(2,6- diphenylphenyl)formamido]ethyl}pentanamide (3 entities in total) |
Functional Keywords | biotin-binding protein, avidin, biotin, strain, biotinylated, steric clash, strained, hindered, force, ligand series, affinity |
Biological source | STREPTOMYCES AVIDINII |
Total number of polymer chains | 2 |
Total formula weight | 27648.06 |
Authors | Fairhead, M.,Shen, D.,Chan, L.K.M.,Lowe, E.D.,Donohoe, T.J.,Howarth, M. (deposition date: 2014-02-06, release date: 2014-08-06, Last modification date: 2023-12-20) |
Primary citation | Fairhead, M.,Shen, D.,Chan, L.K.M.,Lowe, E.D.,Donohoe, T.J.,Howarth, M. Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction. Bioorg.Med.Chem., 22:5476-, 2014 Cited by PubMed: 25128469DOI: 10.1016/J.BMC.2014.07.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.06 Å) |
Structure validation
Download full validation report