4BS2

NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA

Summary for 4BS2

• Entry DOI: 10.2210/pdb4bs2/pdb
• NMR Information: BMRB: 19290
• Descriptor: TAR DNA-BINDING PROTEIN 43, 5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3' (2 entities in total)
• Functional Keywords: transcription, hnrnp, cystic fibrosis, neurodegeneration, isotope-labelled rna, hammerhead ribozyme
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : Q13148
• Total number of polymer chains: 2
• Total formula weight: 23873.09

Authors

Lukavsky, P.J.,Daujotyte, D.,Tollervey, J.R.,Ule, J.,Stuani, C.,Buratti, E.,Baralle, F.E.,Damberger, F.F.,Allain, F.H.T. (deposition date: 2013-06-06, release date: 2013-11-13, Last modification date: 2023-06-14)

• Primary citation: Lukavsky, P.J.,Daujotyte, D.,Tollervey, J.R.,Ule, J.,Stuani, C.,Buratti, E.,Baralle, F.E.,Damberger, F.F.,Allain, F.H.T.; Molecular Basis of Ug-Rich RNA Recognition by the Human Splicing Factor Tdp-43; Nat.Struct.Mol.Biol., 20:1443-, 2013; PubMed: 24240615; DOI: 10.1038/NSMB.2698

Experimental method

SOLUTION NMR