4BBG
Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol
Summary for 4BBG
Entry DOI | 10.2210/pdb4bbg/pdb |
Related | 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B |
Descriptor | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | cell cycle, mitosis, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 1 |
Total formula weight | 42047.87 |
Authors | Kaan, H.Y.K.,Kozielski, F. (deposition date: 2012-09-22, release date: 2013-05-15, Last modification date: 2023-12-20) |
Primary citation | Good, J.A.D.,Wang, F.,Rath, O.,Kaan, H.Y.K.,Talapatra, S.K.,Podgorski, D.,Mackay, S.P.,Kozielski, F. Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models. J.Med.Chem., 56:1878-, 2013 Cited by PubMed: 23394180DOI: 10.1021/JM3014597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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