4B7R
H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
Summary for 4B7R
Entry DOI | 10.2210/pdb4b7r/pdb |
Related | 4B7J 4B7M 4B7N 4B7Q |
Descriptor | NEURAMINIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | hydrolase, neuraminidase inhibitor, nai, nais, zanamivir, resistance, antiviral resistance |
Biological source | INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) |
Total number of polymer chains | 4 |
Total formula weight | 176052.35 |
Authors | Liu, J.,van der Vries, E.,Vachieri, S.G.,Xiong, X.,Collins, P.J.,Walker, P.A.,Haire, L.F.,Hay, A.J.,Schutten, M.,Osterhaus, A.D.M.E.,Martin, S.R.,Boucher, C.A.B.,Skehel, J.J.,Gamblin, S.J. (deposition date: 2012-08-21, release date: 2012-10-03, Last modification date: 2020-07-29) |
Primary citation | Van Der Vries, E.,Collins, P.J.,Vachieri, S.G.,Xiong, X.,Liu, J.,Walker, P.A.,Haire, L.F.,Hay, A.J.,Schutten, M.,Osterhaus, A.D.M.E.,Martin, S.R.,Boucher, C.A.B.,Skehel, J.J.,Gamblin, S.J. H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis Plos Pathog., 8:2914-, 2012 Cited by PubMed: 23028314DOI: 10.1371/JOURNAL.PPAT.1002914 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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