4AX9

Human thrombin complexed with Napsagatran, RO0466240

Summary for 4AX9

• Entry DOI: 10.2210/pdb4ax9/pdb
• Related: 4AXL 4AXM
• Descriptor: PROTHROMBIN, HIRUDIN VARIANT-1, SODIUM ION, ... (7 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 3
• Total formula weight: 35135.07

Authors

Banner, D.W.,D'Arcy, A.,Winkler, F.K.,Hilpert, K.,Spinelli, S.,Cambillau, C. (deposition date: 2012-06-11, release date: 2012-06-20, Last modification date: 2020-07-29)

• Primary citation: Hilpert, K.,Ackermann, J.,Banner, D.W.,Gast, A.,Gubernator, K.,Hadvary, P.,Labler, L.,Muller, K.,Schmid, G.,Tschopp, T.B.; Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors.; J.Med.Chem., 37:3889-, 1994; PubMed: 7966150; DOI: 10.1021/JM00049A008

Experimental method

X-RAY DIFFRACTION (1.9 Å)