4AX9
Human thrombin complexed with Napsagatran, RO0466240
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | PROTHROMBIN | polymer | 257 | 29594.1 | 1 | UniProt (P00734) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | THROMBIN, COAGULATION FACTOR II, ACTIVATION PEPTIDE FRAGMENT 1, ACTIVATION PEPTIDE FRAGMENT 2, THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN |
| 2 | B (I) | HIRUDIN VARIANT-1 | polymer | 11 | 1411.5 | 1 | UniProt (P01050) | HIRUDO MEDICINALIS (MEDICINAL LEECH) | HIRUDIN, HIRUDIN-1, HIRUDIN-I, LEPIRUDIN |
| 3 | C (L) | PROTHROMBIN | polymer | 28 | 3303.7 | 1 | UniProt (P00734) Pfam (PF09396) | HOMO SAPIENS (HUMAN) | THROMBIN, COAGULATION FACTOR II, ACTIVATION PEPTIDE FRAGMENT 1, ACTIVATION PEPTIDE FRAGMENT 2, THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN |
| 4 | D, E (H) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | F (H) | 2-[[(2S)-4-[[(3S)-1-carbamimidoylpiperidin-3-yl]methylamino]-2-(naphthalen-2-ylsulfonylamino)-4-oxidanylidene-butanoyl] -cyclopropyl-amino]ethanoic acid | non-polymer | 558.6 | 1 | Chemie (N5N) | |||
| 6 | G (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | H, I, J (H, I, L) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 34309.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 825.8 | |
| All* | Total formula weight | 35135.1 |
