4ASX

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C

Summary for 4ASX

• Entry DOI: 10.2210/pdb4asx/pdb
• Descriptor: ACTIVIN RECEPTOR TYPE-2A, 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2H-pyrido[3,4-b]indol-1-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, protein kinase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 74194.40

Authors

Williams, E.,Chaikuad, A.,Canning, P.,Kochan, G.,Mahajan, P.,Cooper, C.D.O.,Beltrami, A.,Krojer, T.,Pohl, B.,Bracher, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A. (deposition date: 2012-05-03, release date: 2012-05-23, Last modification date: 2023-12-20)

• Primary citation: Williams, E.,Chaikuad, A.,Canning, P.,Mahajan, P.,Cooper, C.D.O.,Beltrami, A.,Krojer, T.,Huber, K.,Bracher, F.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.; Crystal Structure of Activin Receptor Type-Iia (Acvr2A) Kinase Domain in Complex with a Beta- Carboline Inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)