4ASX

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
A	0016020	cellular_component	membrane
B	0004672	molecular_function	protein kinase activity
B	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 6OJ A 1487

Chain	Residue
A	ALA199
A	LEU329
A	ASP340
A	ALA217
A	LYS219
A	LEU247
A	THR267
A	ALA268
A	PHE269
A	HIS270
A	ASN327

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 6OJ B 1487

Chain	Residue
B	GLY201
B	ALA217
B	LYS219
B	LEU247
B	ALA268
B	PHE269
B	HIS270
B	ASN327
B	LEU329
B	ASP340
B	HOH2026

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1488

Chain	Residue
A	GLN-2
A	GLN-2
A	HOH2055
A	HOH2056

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 1488

Chain	Residue
B	ASN-6
B	PRO191
B	GLN193
B	GLN210
B	LEU212

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 1489

Chain	Residue
B	GLN210
B	ASN213

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 1490

Chain	Residue
B	GLU234
B	VAL235
B	ALA344
B	LEU345
B	LYS346
B	HOH2032
B	HOH2113

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1489

Chain	Residue
A	ARG255
A	GLY256
A	HOH2059
A	HOH2059
A	HOH2060
A	HOH2182

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1490

Chain	Residue
A	ASN231
A	GLU234
A	VAL235
A	ALA344
A	LEU345
A	LYS346
A	HOH2135
A	HOH2183

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 1491

Chain	Residue
B	PHE249
B	HOH2061

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 1492

Chain	Residue
A	GLN483
B	GLY361
B	ARG363

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1491

Chain	Residue
A	ARG438
A	ASP463
A	HIS464
A	HOH2177

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IsHrDIKskNVLL

Chain	Residue	Details
A	ILE318-LEU330

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	293
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---