4AJW
Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers
Summary for 4AJW
Entry DOI | 10.2210/pdb4ajw/pdb |
Related | 2WXE 2WXF 2WXG 2WXH 2WXI 2WXJ 2WXK 2WXL 2WXM 2WXN 2WXO 2WXP 2WXQ 2WXR 2X38 |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-[(1-methyl-1H-benzimidazol-2-yl)methyl]-6-morpholin-4-ylpyrimidin-4(3H)-one (3 entities in total) |
Functional Keywords | transferase, p110d |
Biological source | MUS MUSCULUS (HOUSE MOUSE) |
Total number of polymer chains | 2 |
Total formula weight | 215070.78 |
Authors | Certal, V.,Halley, F.,Virone-Oddos, A.,Delorme, C.,Karlsson, A.,Rak, A.,Thompson, F.,Filoche-Romme, B.,El-Ahmad, Y.,Carry, J.C.,Abecassis, P.Y.,Lejeune, P.,Bonnevaux, H.,Nicolas, J.P.,Bertrand, T.,Marquette, J.P.,Michot, N.,Benard, T.,Below, P.,Vade, I.,Chatreaux, F.,Lebourg, G.,Pilorge, F.,Angouillant-Boniface, O.,Louboutin, A.,Lengauer, C.,Schio, L. (deposition date: 2012-02-20, release date: 2012-05-16, Last modification date: 2023-12-20) |
Primary citation | Certal, V.,Halley, F.,Virone-Oddos, A.,Delorme, C.,Karlsson, A.,Rak, A.,Thompson, F.,Filoche-Romm, B.,El-Ahmad, Y.,Carry, J.C.,Abecassis, P.Y.,Lejeune, P.,Vincent, L.,Bonnevaux, H.,Nicolas, J.P.,Bertrand, T.,Marquette, J.P.,Michot, N.,Benard, T.,Below, P.,Vade, I.,Chatreaux, F.,Lebourg, G.,Pilorge, F.,Angouillant-Boniface, O.,Louboutin, A.,Lengauer, C.,Schio, L. Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. J.Med.Chem., 55:4788-, 2012 Cited by PubMed: 22524426DOI: 10.1021/JM300241B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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