4A9C
Crystal structure of human SHIP2 in complex with biphenyl 2,3',4,5',6- pentakisphosphate
Summary for 4A9C
Entry DOI | 10.2210/pdb4a9c/pdb |
Descriptor | PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2, BIPHENYL 2,3',4,5',6-PENTAKISPHOSPHATE (3 entities in total) |
Functional Keywords | sgc, phosphatidylinositol, signalling, structural genomics consortium stockholm, magnesium binding, hydrolase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytosol: O15357 |
Total number of polymer chains | 2 |
Total formula weight | 73121.81 |
Authors | Tresaugues, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Edwards, A.M.,Ekblad, T.,Graslund, S.,Karlberg, T.,Mills, S.J.,Moche, M.,Nyman, T.,Persson, C.,Potter, B.V.L.,Schuler, H.,Thorsell, A.G.,Weigelt, J.,Nordlund, P. (deposition date: 2011-11-25, release date: 2012-05-30, Last modification date: 2023-12-20) |
Primary citation | Mills, S.J.,Persson, C.,Cozier, G.,Thomas, M.P.,Tresaugues, L.,Erneux, C.,Riley, A.M.,Nordlund, P.,Potter, B.V.L. A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with Ship2 Provides a Rationale for Drug Discovery. Acs Chem.Biol., 7:822-, 2012 Cited by PubMed: 22330088DOI: 10.1021/CB200494D PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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