465D
STRUCTURE OF THE TOPOISOMERASE II POISON BOUND TO DNA
Summary for 465D
Entry DOI | 10.2210/pdb465d/pdb |
Descriptor | DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total) |
Functional Keywords | topoisomerase ii poison, hexanucleotide, d(cgtacg)2, 9-amino-daca, dna |
Total number of polymer chains | 1 |
Total formula weight | 2425.97 |
Authors | Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P. (deposition date: 1999-04-14, release date: 1999-08-25, Last modification date: 2024-04-03) |
Primary citation | Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P. Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2. Biochemistry, 38:9221-9233, 1999 Cited by PubMed: 10413496DOI: 10.1021/bi990352m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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