465D

STRUCTURE OF THE TOPOISOMERASE II POISON BOUND TO DNA

Summary for 465D

DescriptorDNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total)
Functional Keywordstopoisomerase ii poison, hexanucleotide, d(cgtacg)2, 9-amino-daca, dna
Total number of polymer chains1
Total molecular weight2425.97
Authors
Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P. (deposition date: 1999-04-14, release date: 1999-08-25, Last modification date: 2018-02-14)
Primary citation
Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P.
Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.
Biochemistry, 38:9221-9233, 1999
PubMed: 10413496 (PDB entries with the same primary citation)
DOI: 10.1021/bi990352m
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

Clashscore0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution