45CX

CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM PLASMODIUM FALCIPARUM COMPLEXED WITH LYS-AMS

Summary for 45CX

• Entry DOI: 10.2210/pdb45cx/pdb
• Descriptor: Lysine--tRNA ligase, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, FORMIC ACID, ... (5 entities in total)
• Functional Keywords: malaria, lysrs, lys-ams, lysyl-adenylate analog, inhibitor, ligase
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 4
• Total formula weight: 237209.98

Authors

Manickam, Y.,Sharma, V.K.,Bagale, S.,Pradeepkumar, P.I.,Sharma, A. (deposition date: 2026-08-24, release date: 2026-10-21)

• Primary citation: Mittal, P.,Sharma, V.K.,Bagale, S.,Nayak, K.H.,Manickam, Y.,Pradeepkumar, P.I.,Sharma, A.; Dual-Site Binding of an Aminoacyl-Adenylate Mimetic Stabilizes an Inactive Conformation of Plasmodium falciparum Lysyl-tRNA Synthetase; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.87 Å)