3ZPS
Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
Summary for 3ZPS
Entry DOI | 10.2210/pdb3zps/pdb |
Related | 3ZPT 3ZPU |
Descriptor | PROTEASE, CHLORIDE ION, methyl N-[(2S)-1-[2-[(4-bromophenyl)methyl]-2-[(4R)-5-[[(2S)-3,3-dimethyl-1-oxidanylidene-1-(prop-2-enylamino)butan-2-yl]amino]-4-oxidanyl-5-oxidanylidene-4-(phenylmethyl)pentyl]hydrazinyl]-3,3-dimethyl-1-oxidanylidene-butan-2-yl]carbamate, ... (4 entities in total) |
Functional Keywords | hydrolase, protease inhibitor, rational drug design |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22388.41 |
Authors | Joshi, A.,Veron, J.B.,Unge, J.,Rosenquist, A.,Wallberg, H.,Samuelsson, B.,Hallberg, A.,Larhed, M. (deposition date: 2013-03-01, release date: 2013-11-06, Last modification date: 2018-01-17) |
Primary citation | Joshi, A.,Veron, J.B.,Unge, J.,Rosenquist, A.,Wallberg, H.,Samuelsson, B.,Hallberg, A.,Larhed, M. Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors. J.Med.Chem., 56:8999-, 2013 Cited by PubMed: 24160253DOI: 10.1021/JM400811D PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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