3ZPQ

Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound (compound 19)

Summary for 3ZPQ

• Entry DOI: 10.2210/pdb3zpq/pdb
• Related: 3ZPR
• Descriptor: BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ... (6 entities in total)
• Functional Keywords: membrane protein, gpcr, fragment screening, aryl piperazine, structure based drug design
• Biological source: MELEAGRIS GALLOPAVO (TURKEY)
• Total number of polymer chains: 2
• Total formula weight: 77715.36

Authors

Christopher, J.A.,Congreve, M.,Dore, A.S.,Marshall, F.H.,Myszka, D.G.,Brown, J.,Koglin, M.,Tehan, B.,Errey, J.C.,Tate, C.G.,Warne, T. (deposition date: 2013-03-01, release date: 2013-04-03, Last modification date: 2023-12-20)

• Primary citation: Christopher, J.,Brown, J.,Dore, A.,Errey, J.,Koglin, M.,Marshall, F.H.,Myszka, D.,Rich, R.L.,Tate, C.G.,Tehan, B.,Warne, T.,Congreve, M.; Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.; J.Med.Chem., 56:3446-, 2013; PubMed: 23517028; DOI: 10.1021/JM400140Q

Experimental method

X-RAY DIFFRACTION (2.8 Å)