3ZPG

Acinetobacter baumannii RibD, form 2

3ZPG の概要

• エントリーDOI: 10.2210/pdb3zpg/pdb
• 関連するPDBエントリー: 3ZPC
• 分子名称: RIBD, ZINC ION, SULFATE ION, ... (9 entities in total)
• 機能のキーワード: reductase, deaminase, hydrolase
• 由来する生物種: ACINETOBACTER BAUMANNII
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43478.79

構造登録者

Dawson, A.,Trumper, P.,Chrysostomou, G.,Hunter, W.N. (登録日: 2013-02-27, 公開日: 2013-03-27, 最終更新日: 2023-12-20)

主引用文献

Dawson, A.,Trumper, P.,Chrysostomou, G.,Hunter, W.N.
Structure of Diaminohydroxyphosphoribosylaminopyrimidine Deaminase/5-Amino-6-(5-Phosphoribosylamino)Uracil Reductase from Acinetobacter Baumannii.
Acta Crystallogr.,Sect.F, 69:611-, 2013

PubMed Abstract: The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 Å resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain.

PubMed: 23722836
DOI: 10.1107/S174430911301292X

実験手法

X-RAY DIFFRACTION (1.99 Å)