3ZO3

The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors

3ZO3 の概要

• エントリーDOI: 10.2210/pdb3zo3/pdb
• 関連するPDBエントリー: 3ZO1 3ZO2 3ZO4
• 分子名称: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, 6-(2,9-DIAZASPIRO[5.5]UNDECAN-2-YL)-9H-PURINE, ... (6 entities in total)
• 機能のキーワード: transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: BOS TAURUS (BOVINE); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44009.02

構造登録者

Allen, C.E.,Chow, C.L.,Caldwell, J.J.,Westwood, I.M.,van Montfort, R.L.,Collins, I. (登録日: 2013-02-20, 公開日: 2013-03-06, 最終更新日: 2023-12-20)

• 主引用文献: Allen, C.E.,Chow, C.L.,Caldwell, J.J.,Westwood, I.M.,van Montfort, R.L.,Collins, I.; Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.; Bioorg. Med. Chem., 21:5707-5724, 2013; PubMed: 23920481; DOI: 10.1016/j.bmc.2013.07.021

実験手法

X-RAY DIFFRACTION (2.1 Å)