3ZO2

The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors

Summary for 3ZO2

Entry DOI	10.2210/pdb3zo2/pdb
Related	3ZO1 3ZO3 3ZO4
Descriptor	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, 6-(2,9-Diazaspiro[5.5]undecan-9-yl)-9H-purine, ... (6 entities in total)
Functional Keywords	transferase-inhibitor complex, transferase/inhibitor
Biological source	BOS TAURUS (BOVINE) More
Total number of polymer chains	2
Total formula weight	43798.69
Authors	Allen, C.E.,Chow, C.L.,Caldwell, J.J.,Westwood, I.M.,van Montfort, R.L.,Collins, I. (deposition date: 2013-02-20, release date: 2013-03-06, Last modification date: 2023-12-20)
Primary citation	Allen, C.E.,Chow, C.L.,Caldwell, J.J.,Westwood, I.M.,van Montfort, R.L.,Collins, I. Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases. Bioorg. Med. Chem., 21:5707-5724, 2013 Cited by PubMed: 23920481 DOI: 10.1016/j.bmc.2013.07.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation