3ZML

Anopheles funestus glutathione-s-transferase epsilon 2 (GSTe2) protein structure from different alelles: A single amino acid change confers high level of DDT resistance and cross resistance to permethrin in a major malaria vector in Africa

Summary for 3ZML

Entry DOI	10.2210/pdb3zml/pdb
Related	3ZMK
Descriptor	GLUTATHIONE S-TRANSFERASE E2, GLUTATHIONE (3 entities in total)
Functional Keywords	transferase
Biological source	ANOPHELES FUNESTUS
Total number of polymer chains	2
Total formula weight	51180.70
Authors	Yunta, C.,Albert, A. (deposition date: 2013-02-11, release date: 2014-01-22, Last modification date: 2023-12-20)
Primary citation	Riveron, J.M.,Yunta, C.,Ibrahim, S.S.,Djouaka, R.,Irving, H.,Menze, B.D.,Ismail, H.M.,Hemingway, J.,Ranson, H.,Albert, A.,Wondji, C.S. A Single Mutation in the Gste2 Gene Allows Tracking of Metabolically-Based Insecticide Resistance in a Major Malaria Vector. Genome Biol., 15:R27-, 2014 Cited by PubMed Abstract: Metabolic resistance to insecticides is the biggest threat to the continued effectiveness of malaria vector control. However, its underlying molecular basis, crucial for successful resistance management, remains poorly characterized. PubMed: 24565444 DOI: 10.1186/GB-2014-15-2-R27 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.639 Å)

Structure validation