3ZLX
Crystal structure of MEK1 in complex with fragment 18
Summary for 3ZLX
Entry DOI | 10.2210/pdb3zlx/pdb |
Related | 3ZLS 3ZLW 3ZLY 3ZM4 |
Descriptor | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, 7-choro-6-[(3R)-pyrrolidin-3-ylmethoxy]isoquinolin-1(2H)-one (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 39195.61 |
Authors | Amaning, K.,Lowinsky, M.,Vallee, F.,Steier, V.,Marcireau, C.,Ugolini, A.,Delorme, C.,McCort, G.,Andouche, C.,Vougier, S.,Llopart, S.,Halland, N.,Rak, A. (deposition date: 2013-02-04, release date: 2013-05-22, Last modification date: 2024-05-08) |
Primary citation | Amaning, K.,Lowinski, M.,Vallee, F.,Steier, V.,Marcireau, C.,Ugolini, A.,Delorme, C.,Foucalt, F.,Mccort, G.,Derimay, N.,Andouche, C.,Vougier, S.,Llopart, S.,Halland, N.,Rak, A. The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23:3620-, 2013 Cited by PubMed: 23648182DOI: 10.1016/J.BMCL.2013.04.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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