3ZLX
Crystal structure of MEK1 in complex with fragment 18
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 | polymer | 348 | 38916.9 | 1 | UniProt (Q02750) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | MAP KINASE KINASE 1, MAPKK 1, MKK1, ERK ACTIVATOR KINASE 1, MAPK/ERK KINASE 1, MEK 1, MEK1 |
| 2 | B (A) | 7-choro-6-[(3R)-pyrrolidin-3-ylmethoxy]isoquinolin-1(2H)-one | non-polymer | 278.7 | 1 | Chemie (5EZ) PubChem (73348939) | |||
| 3 | C (A) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 37 - 383 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 36 | - | expression tag |
| Asn 298 | Ser 298 | engineered mutation |
| Lys 299 | Ser 299 | engineered mutation |
| Lys 300 | Tyr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38916.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 278.7 | |
| All* | Total formula weight | 39195.6 |
