3ZLQ
BACE2 XAPERONE COMPLEX
Summary for 3ZLQ
Entry DOI | 10.2210/pdb3zlq/pdb |
Descriptor | BETA-SECRETASE 2, XA4813, 5-Ethoxy-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide, ... (4 entities in total) |
Functional Keywords | hydrolase-immune system complex, hydrolase/immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Membrane; Single-pass type I membrane protein: Q9Y5Z0 |
Total number of polymer chains | 4 |
Total formula weight | 111216.50 |
Authors | Kuglstatter, A.,Stihle, M. (deposition date: 2013-02-04, release date: 2013-05-01, Last modification date: 2013-06-05) |
Primary citation | Hilpert, H.,Guba, W.,Woltering, T.J.,Wostl, W.,Pinard, E.,Mauser, H.,Mayweg, A.V.,Rogers-Evans, M.,Humm, R.,Krummenacher, D.,Muser, T.,Schnider, C.,Jacobsen, H.,Ozmen, L.,Bergadano, A.,Banner, D.W.,Hochstrasser, R.,Kuglstatter, A.,David-Pierson, P.,Fischer, H.,Polara, A.,Narquizian, R. Beta-Secretase (Bace1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer'S Disease. J.Med.Chem., 56:3980-, 2013 Cited by PubMed: 23590342DOI: 10.1021/JM400225M PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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