3ZEP

Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor

3ZEP の概要

• エントリーDOI: 10.2210/pdb3zep/pdb
• 分子名称: TYROSINE-PROTEIN KINASE JAK3, 2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1S)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase, stat5, stat6, interleukin-2, common-gamma chain, atp site kinase inhibitor, cancer, scid, severe combined immunodeficiency
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : P52333
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 133664.06

構造登録者

Kuglstatter, A.,Jestel, A.,Nagel, S.,Boettcher, J.,Blaesse, M. (登録日: 2012-12-06, 公開日: 2013-12-11, 最終更新日: 2016-09-14)

• 主引用文献: Jaime-Figueroa, S.,De Vicente, J.,Hermann, J.,Jahangir, A.,Jin, S.,Kuglstatter, A.,Lynch, S.M.,Menke, J.,Niu, L.,Patel, V.,Shao, A.,Soth, M.,Vu, M.D.,Yee, C.; Discovery of a Series of Novel 5H-Pyrrolo[2,3-B]Pyrazine-2-Phenyl Ethers, as Potent Jak3 Kinase Inhibitors.; Bioorg.Med.Chem.Lett., 23:2522-, 2013; PubMed: 23541670; DOI: 10.1016/J.BMCL.2013.03.015

実験手法

X-RAY DIFFRACTION (2.35 Å)