3WWJ
Crystal structure of an engineered sitagliptin-producing transaminase, ATA-117-Rd11
Summary for 3WWJ
Entry DOI | 10.2210/pdb3wwj/pdb |
Related | 3WWH 3WWI |
Descriptor | (R)-amine transaminase, PYRIDOXAL-5'-PHOSPHATE (3 entities in total) |
Functional Keywords | transaminase, amine-pyruvate aminotransferase, pyridoxal-5'-phosphate, multi-domain protein (alpha and beta), fold class iv plp-dependent enzyme, transferase |
Biological source | Arthrobacter sp. KNK168 |
Total number of polymer chains | 12 |
Total formula weight | 442250.32 |
Authors | Guan, L.J.,Ohtsuka, J.,Okai, M.,Miyakawa, T.,Mase, T.,Zhi, Y.,Hou, F.,Ito, N.,Yasohara, Y.,Tanokura, M. (deposition date: 2014-06-18, release date: 2015-08-12, Last modification date: 2018-11-21) |
Primary citation | Guan, L.J.,Ohtsuka, J.,Okai, M.,Miyakawa, T.,Mase, T.,Zhi, Y.,Hou, F.,Ito, N.,Iwasaki, A.,Yasohara, Y.,Tanokura, M. A new target region for changing the substrate specificity of amine transaminases. Sci Rep, 5:10753-10753, 2015 Cited by PubMed: 26030619DOI: 10.1038/srep10753 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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