3WSQ
Structure of HER2 with an Fab
Summary for 3WSQ
| Entry DOI | 10.2210/pdb3wsq/pdb |
| Descriptor | Receptor tyrosine-protein kinase erbB-2, Antibody Light Chain, Antibody Heavy Chain (3 entities in total) |
| Functional Keywords | kinase, transferase-immune system complex, transferase/immune system |
| Biological source | Homo sapiens (human) More |
| Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
| Total number of polymer chains | 3 |
| Total formula weight | 107840.00 |
| Authors | Fu, W.Y.,Wang, Y.X.,Zhou, L.J. (deposition date: 2014-03-20, release date: 2015-03-25, Last modification date: 2017-11-22) |
| Primary citation | Fu, W.,Wang, Y.,Zhang, Y.,Xiong, L.,Takeda, H.,Ding, L.,Xu, Q.,He, L.,Tan, W.,Bethune, A.N.,Zhou, L. Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies. MAbs, 6:978-990, 2014 Cited by PubMed: 24838231DOI: 10.4161/mabs.28786 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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