3WO3

Crystal structure of IL-18 in complex with IL-18 receptor alpha

Summary for 3WO3

• Entry DOI: 10.2210/pdb3wo3/pdb
• Related: 3WO2 3WO4
• Descriptor: Interleukin-18, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: binary complex, beta trefoil fold (ligand), three immunoglobulin-like domains (receptor), immunity, inflammation, autoimmunity, allergy, interleukin-18 receptor beta, glycosylation, serum, membrane, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 346959.29

Authors

Tsutsumi, N.,Kimura, T.,Arita, K.,Ariyoshi, M.,Ohnishi, H.,Kondo, N.,Shirakawa, M.,Kato, Z.,Tochio, H. (deposition date: 2013-12-19, release date: 2014-12-17, Last modification date: 2023-11-08)

• Primary citation: Tsutsumi, N.,Kimura, T.,Arita, K.,Ariyoshi, M.,Ohnishi, H.,Yamamoto, T.,Zuo, X.,Maenaka, K.,Park, E.Y.,Kondo, N.,Shirakawa, M.,Tochio, H.,Kato, Z.; The structural basis for receptor recognition of human interleukin-18; Nat Commun, 5:5340-5340, 2014; PubMed: 25500532; DOI: 10.1038/ncomms6340

Experimental method

X-RAY DIFFRACTION (3.1 Å)