3WO3
Crystal structure of IL-18 in complex with IL-18 receptor alpha
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006955 | biological_process | immune response |
| B | 0004908 | molecular_function | interleukin-1 receptor activity |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006954 | biological_process | inflammatory response |
| C | 0006955 | biological_process | immune response |
| D | 0004908 | molecular_function | interleukin-1 receptor activity |
| E | 0005125 | molecular_function | cytokine activity |
| E | 0005615 | cellular_component | extracellular space |
| E | 0006954 | biological_process | inflammatory response |
| E | 0006955 | biological_process | immune response |
| F | 0004908 | molecular_function | interleukin-1 receptor activity |
| G | 0005125 | molecular_function | cytokine activity |
| G | 0005615 | cellular_component | extracellular space |
| G | 0006954 | biological_process | inflammatory response |
| G | 0006955 | biological_process | immune response |
| H | 0004908 | molecular_function | interleukin-1 receptor activity |
| I | 0005125 | molecular_function | cytokine activity |
| I | 0005615 | cellular_component | extracellular space |
| I | 0006954 | biological_process | inflammatory response |
| I | 0006955 | biological_process | immune response |
| J | 0004908 | molecular_function | interleukin-1 receptor activity |
| K | 0005125 | molecular_function | cytokine activity |
| K | 0005615 | cellular_component | extracellular space |
| K | 0006954 | biological_process | inflammatory response |
| K | 0006955 | biological_process | immune response |
| L | 0004908 | molecular_function | interleukin-1 receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Site: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334240","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 395 |
| Details | Domain: {"description":"Ig-like C2-type 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 552 |
| Details | Domain: {"description":"Ig-like C2-type 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25500532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WO3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WO4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25261253","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WO3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WO4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
