3WMC

Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q2

3WMC の概要

• エントリーDOI: 10.2210/pdb3wmc/pdb
• 関連するPDBエントリー: 3NSM 3NSN 3OZO 3OZP 3S6T 3VTR 3WMB
• 分子名称: Beta-hexosaminidase, 6-(dimethylamino)-2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: chitinase, glycosyl hydrolase, insect, ostrinia furnacalis, hydrolase
• 由来する生物種: Ostrinia furnacalis (Asian corn borer)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66389.80

構造登録者

Chen, L.,Zhou, Y.,Chen, L.,Yang, Q. (登録日: 2013-11-16, 公開日: 2014-11-05, 最終更新日: 2023-11-08)

• 主引用文献: Liu, T.,Guo, P.,Zhou, Y.,Wang, J.,Chen, L.,Yang, H.,Qian, X.,Yang, Q.; A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs; Sci Rep, 4:6188-6188, 2014; PubMed: 25155420; DOI: 10.1038/srep06188

実験手法

X-RAY DIFFRACTION (2.095 Å)