3WIZ

Crystal structure of Bcl-xL in complex with compound 10

Summary for 3WIZ

• Entry DOI: 10.2210/pdb3wiz/pdb
• Related: 3WIX 3WIY
• Descriptor: Bcl-2-like protein 1, 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: regulation, apoptosis
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817
• Total number of polymer chains: 2
• Total formula weight: 42732.75

Authors

Sogabe, S.,Igaki, S.,Hayano, Y. (deposition date: 2013-09-26, release date: 2013-11-27, Last modification date: 2023-11-08)

• Primary citation: Tanaka, Y.,Aikawa, K.,Nishida, G.,Homma, M.,Sogabe, S.,Igaki, S.,Hayano, Y.,Sameshima, T.,Miyahisa, I.,Kawamoto, T.,Tawada, M.,Imai, Y.,Inazuka, M.,Cho, N.,Imaeda, Y.,Ishikawa, T.; Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.; J.Med.Chem., 56:9635-9645, 2013; PubMed: 24215352; DOI: 10.1021/jm401170c

Experimental method

X-RAY DIFFRACTION (2.45 Å)