3WIY

Crystal structure of Mcl-1 in complex with compound 10

Summary for 3WIY

Entry DOI	10.2210/pdb3wiy/pdb
Related	3WIX 3WIZ
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid (3 entities in total)
Functional Keywords	regulation, apoptosis
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass membrane protein (Potential): Q07820
Total number of polymer chains	6
Total formula weight	114550.32
Authors	Sogabe, S.,Igaki, S.,Hayano, Y. (deposition date: 2013-09-26, release date: 2013-11-27, Last modification date: 2023-11-08)
Primary citation	Tanaka, Y.,Aikawa, K.,Nishida, G.,Homma, M.,Sogabe, S.,Igaki, S.,Hayano, Y.,Sameshima, T.,Miyahisa, I.,Kawamoto, T.,Tawada, M.,Imai, Y.,Inazuka, M.,Cho, N.,Imaeda, Y.,Ishikawa, T. Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J.Med.Chem., 56:9635-9645, 2013 Cited by PubMed: 24215352 DOI: 10.1021/jm401170c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation