3WIY
Crystal structure of Mcl-1 in complex with compound 10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 161 | 18204.7 | 6 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (human) | Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid | non-polymer | 887.0 | 6 | Chemie (LC6) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 172 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 167 | - | expression tag |
| Pro 168 | - | expression tag |
| Leu 169 | - | expression tag |
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 109228.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 5322.2 | |
| All* | Total formula weight | 114550.3 |
