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3WIX

Crystal structure of Mcl-1 in complex with compound 4

Summary for 3WIX
Entry DOI10.2210/pdb3wix/pdb
Related3WIY 3WIZ
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1, 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid (3 entities in total)
Functional Keywordsregulation, apoptosis
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass membrane protein (Potential): Q07820
Total number of polymer chains4
Total formula weight74684.68
Authors
Sogabe, S.,Igaki, S.,Hayano, Y. (deposition date: 2013-09-26, release date: 2013-11-27, Last modification date: 2023-11-08)
Primary citationTanaka, Y.,Aikawa, K.,Nishida, G.,Homma, M.,Sogabe, S.,Igaki, S.,Hayano, Y.,Sameshima, T.,Miyahisa, I.,Kawamoto, T.,Tawada, M.,Imai, Y.,Inazuka, M.,Cho, N.,Imaeda, Y.,Ishikawa, T.
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56:9635-9645, 2013
Cited by
PubMed: 24215352
DOI: 10.1021/jm401170c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

건을2024-03-27부터공개중

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